Santo Domingo de los Colorados, often simply referred to as Santo Domingo (Quechua: Tsachila), is an Ecuadorian city and seat of the canton that bears its name and the Santo Domingo de los Tsáchilas Province. It is the fourth most populous city in Ecuador, with a population of over 460,000, and is an important commercial and industrial center.
The name, "de los Colorados", refers to a local ethnic group, the Tsáchila, and the custom of men in that tribe to dye their hair with extract of the achiote plant; hence "Santo Dominigo de los Colorados" or "Santo Domingo of the Dyed." This group, which is indigenous to the area, is recognised with a substantial statue near the town center.