Muridke (Punjabi, ), is a major commercial city and headquarters of Muridke Tehsil in Shaikhupura District in Punjab, Pakistan. It is situated near the city of Lahore, Pakistan at an elevation of 205 m (675 ft) and is situated on the famous Grand Trunk Road and at the crossroads to Shaikhupur, Kala Shah kaku, Gujranwala, Narang Mandi and Narowal. The economic and social life of the city, which has three police stations and a rail station, mainly depends on Lahore.
In 2005 Muridke became the headquarters of the newly created Muridke Tehsil of Sheikhupura District.
The main offices of the banned Lashkar-e-Taiba and Markaz Ad-Dawa-wal-Irshad groups are located in Muridke, and in November 1999 three bombs exploded during a gathering of members, killing one and injuring 26 others.