Itaqui is a municipality in Brazil, located in the southwestern part of the state of Rio Grande do Sul, close to the Argentinian border, between Uruguaiana and São Borja. It sits at a mean altitude of 57 meters (187 ft), by the Uruguay River. Its population is currently estimated at 37,489.
The municipality contains part of the 4392 ha São Donato Biological Reserve, a strictly protected conservation unit created in 1975 that protects an area of wetlands on the Butuí River, a tributary of the Uruguay River.