Guelmim-Es Semara (كلميم السمارة) was formerly one of the sixteen regions of Morocco from 1997 to 2015. It covered an area of 122,825 km² and had a population of 501,921 (2014 census). The regional capital was Guelmim.
The southern half of Guelmin-Es Semara forms part of the Western Sahara. The region is bordered to the north by Souss-Massa-Drâa and to the west by Laayoune-Boujdour-Sakia El Hamra, with the Algerian province of Tindouf to the east. Its disputed territory in the Western Sahara borders the Mauritanian Tiris Zemmour Region. Guelmin-Es Semara has a coastline on the Atlantic Ocean, with the Spanish Canary Islands lying off it. The Draa River, at 1,100 km the longest in Morocco, flows into the Ocean near Tan-Tan.
The region was made up of the following provinces:
* Assa-Zag Province
* Es Smara Province
* Guelmim Province
* Tan-Tan Province
* Tata Province
==Municipalities by population (2004 census) ==
* Guelmin, Guelmim Province: 95,599