Guadalupe is the third-largest city in the state of Zacatecas in Mexico. It lies adjacent to the east side of the city of Zacatecas and is a component of the Zacatecas-Guadalupe metropolitan area. The city had a 2005 census population of 99,572 inhabitants and serves as municipal seat of the municipality of Guadalupe, which had a population of 129,387. The municipality has an area of 804 km² (310.4 sq mi). The largest other community is the town of Tacoaleche.