Artigas Department (Departamento de Artigas, ) is the northernmost department of Uruguay, located in its northwestern region. Its capital is the city of Artigas, which borders on the Brazilian city of Quaraí. Artigas Department has an area of 11928 km2, making it the fifth largest in the country. The population is 73,378 inhabitants, according to the 2011 census.
It is bordered on the north and east by Brazil, from which it is separated by the Cuareim River. To the south, Artigas Department borders on Salto Department, and to the west is Argentina, from which it is separated by the Uruguay River. Artigas is the only Uruguayan department that borders two other countries.
The department and its capital city are named after José Gervasio Artigas (1764–1850), leader of the Orientales (inhabitants of the Banda Oriental, the Eastern bank of the Uruguay River) during Uruguay's wars of independence.